Endocrine Abstracts

Introduction: Thyroid nodules are commonly encountered in clinical practice, the main diagnostic problem being the benign or malignant nature of the nodules. Fine-needle aspiration biopsy (FNAB) is a standard diagnostic test for evaluating thyroid nodules. Several studies have showed that the use of ultrasound guidance (US-FNAB) improves the diagnostic accuracy of aspiration biopsies in comparison with palpation guidance (P-FNAB) alone.Patients and metho...

Introduction: Pancreatic neuroendocrine tumors (PNET) are rare, with an incidence of 1/100,000/year. Chromogranin A (CgA) is the most valuable marker in the diagnosis and monitoring of PNET. One of the disadvantages is its low specificity and the existence of a number of processes leading to an increase in its concentration, which often results in confusion and diagnostic difficulties.Case report: We present a 44-years-old female patient...

Introduction: Epidemiological and clinical studies have proven direct correlations between chronic stress, inflammation and cancer progression. The inflammatory environment preexisting the malignant change and elevated IGF-1 levels are associated with higher cancer risk, especially through GH effects on cell proliferation and inhibition of apoptosis.Aim: To evaluate the relationship between biological and hormonal stress markers, growth factors and breas...

Introduction: Obesity and insulin resistance have been identified as risk factors for breast cancer and are associated with late-stage diagnosis and poor prognosis. Ghrelin is a unique gut-derived peptide that has major impact in energy homeostasis and weight regulation, with new emerging implications in tumorigenesis process, especially in hormone-dependent cancers.Aim: To evaluate the relationship between ghrelin, clinico-biological parameters of obesi...

Introduction: Nonoccupational postexposure prophylaxis (nPEP) is a three-drug antiretroviral regimen used to decrease the risk for HIV infection after less than 72 h from nonoccupational exposure to body fluids that might contain HIV. The most frequent side effects concern the gastro-intestinal intolerance, renal and hepatic toxicity, with no hormonal imbalance to have been yet reported.Case report: 24 years old male patient, consulted for palpitations, ...

Introduction: Many causes of malabsorbtion of levothyroxine (LT4) in patients with hypothyroidism have been thoroughly described in literature. Pseudomalabsorption, poor compliance of the patient is most common cause of failure of LT4 and/or liothyronine (LT3) treatment.Case report: 27 years old woman, normopondeal, presented from the age of 11 years for short stature. Further investigations found pluritrope pituitary insufficiency ...

Introduction: The coexistence of pituitary adenoma and meningiomas is very rare. It is debatable if meningiomas result as a consequence of hormone dependent growth or secondary to radiation.We report a rare case of coexisting brain tumors: a prolactin secreting pituitary adenoma and two meningiomas in a 54-year-old female patient.Case report: Onset at 46 years with bitemporal hemianopsia, without other clinical complaints. MRI conf...

Introduction: Legg calvé perthes (LCP) is a disease characterized by idiopathic avascular necrosis of the proximal femoral epiphysis caused by decreased blood flow. More frequently in boys between 2 and 12 years of age. LCPD is of unknown etiology.We present two male patients of LCP associated with pituitary disorders.Case presentation: Case 1: g.i.c., 8 years 8 month, was first addressed to the endocrinology department for in...

Background: Normal thyroid function is necessary for the optimal effect of recombinant growth hormone (rhGH) on growth rate. GH therapy in children with GH deficiency (GHD) has yielded conflicting results concerning its impact on thyroid function. Data about patients developing subclinical hypothyroidism (SH) are scanty, but it is thought to be associated with impairment of metabolic profile and lower growth response.Objective: To evaluate the effect of ...

Introduction: Hypophysitis is a chronic inflammatory condition of the pituitary gland which typically presents with hypopituitarism and a pituitary mass. The disease is rare, with an estimated incidence of 1/9000000. Most reported cases are in women during peripartum period and only approximately 15% of reported cases occur in males.Case report: Male patient, aged 57, smoker, with a history of hypertension, just returned from India, presented with anorex...